AFPE Funded Research

AFPE Funds a wide variety of research areas in the pharmaceutical sciences and pharmacy. In the past three years, this research has included:

Drug Development and Drug-Drug Interaction

  • Antibiotics*
  • Anti Cancer Drugs*
  • Biologic Drug Formulation
  • Drug Clearance
  • Drug-Drug Interactions in the Liver
  • Drug Metabolism and Pharmokinetics
  • Oral Drug Permeability*
  • OATP-Medicated Drug-Drug Interaction
  • Drug Targeting
  • Iron Release in Iron Nanoparticle Drug Products

Endocrine Related Disorders

  • Cholestasis*
  • Obesity

Infectious Disease

  • Cystic Fibrosis*
  • Drug-Resistant Streptococcus
  • Herpesvirus*
  • HIV/HIV-1*
  • Influenza*
  • RSV Disease
  • Zika Virus

Kidney Disease

  • Calcium Oxalate Kidney Stones
  • Iron Anemia

Neurodegenerative and Neurological Disorders

  • Alzheimer’s Disease*
  • Epilepsy
  • Neurotrauma
  • Oxidative Stress and Neurodegeneration
  • Parkinson’s Disease*
  • Status Epilepticus
  • Seizures

Oncology

  • Acute Myeloid Leukemia
  • Anti-Cancer Agents
  • Breast Cancer*
  • Bone Therapy*
  • Cancer Cachexia*
  • Cancer Drug Sales
  • Cancer Therapy and Drug Resistance*
  • Cancer Vaccines
  • Canine Cancer
  • Chronic Myeloid Leukemia
  • Glioblastoma*
  • Hepatocellular Carcinoma
  • Lymphatic Melanoma Metastases*
  • Melanoma
  • Ovarian Cancer*
  • Pancreatic Cancer
  • Prostate Cancer*
  • Radiation*
  • Renal Cell Carcinoma*

Pain and Addiction

  • Addiction Therapy
  • Alcoholic Liver Disease*
  • Alcohol Use Disorder
  • Cocaine Addiction
  • Opioid Tolerance
  • Nalaxone
  • Neuropathic Pain

Patient Care

  • Antibiotic Prescribing in Nursing Homes*
  • Contraceptive Counseling in Pediatric Hospitals*
  • Fall-Prevention
  • Microneedle Application
  • Minority Medication Use
  • Pediatric Critical Care*
  • UTI therapy for Hospitalized Patients*
  • Vaccinating in Community Pharmacies*

Reproductive Health

  • Contraceptive Counseling
  • Pre-Term Birth
  • Vaginome Dynamics During Pregnancy

Other Areas

  • Acute Myocardial Infarction*
  • Allergic Disease
  • Arthritis*
  • Autism*
  • Dermatology
  • Hemophilia
  • Inflammatory Disease*
  • Kidney Disease
  • Metabolic Disease*
  • Pharmacy Education and Behavior Research
  • Pharmacy Student Well Being*
  • Pharmacokinetic Interactions
  • Pro-Inflammatory Mediator Suppressants
  • Tuberculosis

* indicates this research is being funded in this fellowship cycle (2019-2020)

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Value of the Pharmaceutical Sciences

Pharmaceutical scientists trained at U.S. schools and colleges of pharmacy are working on breakthrough technologies made possible by combinatorial chemistry, in vitro biopharmaceutical techniques, analytical technologies, bio-materials, and gene transfers-gene therapies such as:

  • Accelerated chemical synthesis and biological screening of millions of compounds to identify as well as optimize structurally novel drug candidates
  • Molecular-based assays using cloned enzymes to predict how the body will metabolize a promising drug candidate before large investments are made in development and animal testing
  • Using cloned metabolizing enzymes or human tissue to analyze and predict toxicity problems and other associated costs prior to a drug’s clinical investigation
  • Implantation or injection of large molecules that are biocompatible over long periods of time to allow delivery of medication at controlled rates over the full course of therapy
  • Providing a gene therapy in a stable form, targeted to a specific site, in a safely administered dosage system

Fundamental changes in drug discovery and development brought about by these new technologies are impacting graduate education in the pharmaceutical sciences both in the graduate curriculum and the research environment. The pharmaceutical sciences disciplines at U.S. college of pharmacy graduate schools include:

The study of drug therapy outcomes in patients with emphasis on factors & mechanisms determining therapy outcomes; the study of genetic & non-genetic factors in the variability of drug response; the study of human pharmacology & therapeutics to improve safe, effective & economical use of medications by patients; and the optimization of drug therapy through generation, integration, & translation of scientific knowledge between the bench and the bedside.

The economic analysis of pharmaceuticals, pharmaco-economic protocol development, pharmaceutical outcomes research, disease management protocols and processes, and management of pharmacy systems and organization.

The design and synthesis of chemical/organic compounds with biological activity and potential use in treatment of disease

The analysis, biosynthesis, production, metabolism, and mechanisms of action of pharmaceutically important plants, animals, and microbes

The design, fabrication, and evaluation of advanced drug delivery and advanced drug level management systems

The use of genetic, molecular, cellular, organ system, and whole animal techniques to examine mechanisms and consequences of drug interactions with living systems

The analysis of adverse effects of new biologically active compounds on living systems, such as tissue injury, reproductive failure, immunosuppression, and cancer