AFPE Funded Research

AFPE Funds a wide variety of research areas in the pharmaceutical sciences and pharmacy, including:

Cardiovascular and Pulmonary

  • Acute Coronary Syndrome
  • Acute Myocardial Infarction
  • Arryhthmia
  • Atrial Fibrillation
  • Cardiovascular Disease
  • Congestive Heart Failure
  • COPD
  • Delta Storage Pool Deficiencies; Thrombocytopenia
  • Heart Failure
  • Ischemic Stroke
  • Lung Disease
  • Thrombosis

Drug Development and Drug-Drug Interaction

  • Green Tea
  • Drug Metabolism
  • Antibiotics
  • Drug-Drug Interactions
  • Drug Resistance

Endocrine Related Disorders

  • Diabetes
  • Hyperlipidemia
  • Obesity

Infectious Disease

  • Drug Resistant M. Tuberculosis
  • Drug Resistant Streptoccus
  • Hepatitis
  • HIV/HIV-1
  • HPV
  • Immunology
  • Influenza
  • Methicillin Resistant Staphylococcus Aureus (MRSA)
  • Microbial Pathogens
  • Respiratory Syncytial Virus (RSV) in Infants
  • Vaccinable Diseases
  • Zika Virus

Neurodegenerative and Neurological Disorders

  • Attention Deficit and Hyperactive Disorders
  • Alzheimer’s Disease
  • Epilepsy
  • Ischemic and Hemorrhagic Stroke
  • Muscular Dystrophy
  • Neurotrauma
  • Parkinson’s Disease

Oncology

  • Brain Tumor (Glioblastoma Multiforme)
  • Cancer Therapy and Drug Resistance
  • Colorectal Adenosarcoma
  • Glioblastoma
  • Liver Cancer
  • Lung and Brain Metastases
  • Melanoma
  • Oncology Care Model
  • Ovarian Cancer
  • Pancreatic Cancer
  • Prostate Cancer
  • Sarcomas

Pain and Addiction

  • Prescription Opioid Analgesics
  • Addiction Therapy
  • Alcohol Dependence
  • Opioid Tolerance
  • Opioid Dosing
  • Naloxone Dosing Behaviors

Patient Care

  • Minority Medication Taking Behaviors
  • Medication Management
  • Transitions of Care

Other Areas

  • Autism
  • Asthma
  • Behavioral Research
  • Drug Induced Liver Injury
  • Genitourinary System Dysfunction
  • Hemophilia
  • Intrahepatic Cholestasis of Pregnancy (ICP)
  • Immunotherapy
  • Infertility
  • Kidney Disease
  • Lung Disease
  • Medication Adherence
  • Mental Illness
  • Myeloid Leukemia
  • Pediatric Cardiac Arrest
  • Pompe Disease (Glycogen Storage Disease Type II)
  • Pre-Term Birth
  • Transitions of Care in Older Adults
  • Vitamin Supplementation/Dosage Evaluation
  • Regulatory Sciences

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Value of the Pharmaceutical Sciences

Pharmaceutical scientists trained at U.S. schools and colleges of pharmacy are working on breakthrough technologies made possible by combinatorial chemistry, in vitro biopharmaceutical techniques, analytical technologies, bio-materials, and gene transfers-gene therapies such as:

  • Accelerated chemical synthesis and biological screening of millions of compounds to identify as well as optimize structurally novel drug candidates
  • Molecular-based assays using cloned enzymes to predict how the body will metabolize a promising drug candidate before large investments are made in development and animal testing
  • Using cloned metabolizing enzymes or human tissue to analyze and predict toxicity problems and other associated costs prior to a drug’s clinical investigation
  • Implantation or injection of large molecules that are biocompatible over long periods of time to allow delivery of medication at controlled rates over the full course of therapy
  • Providing a gene therapy in a stable form, targeted to a specific site, in a safely administered dosage system

Fundamental changes in drug discovery and development brought about by these new technologies are impacting graduate education in the pharmaceutical sciences both in the graduate curriculum and the research environment. The pharmaceutical sciences disciplines at U.S. college of pharmacy graduate schools include:

The study of drug therapy outcomes in patients with emphasis on factors & mechanisms determining therapy outcomes; the study of genetic & non-genetic factors in the variability of drug response; the study of human pharmacology & therapeutics to improve safe, effective & economical use of medications by patients; and the optimization of drug therapy through generation, integration, & translation of scientific knowledge between the bench and the bedside.

The economic analysis of pharmaceuticals, pharmaco-economic protocol development, pharmaceutical outcomes research, disease management protocols and processes, and management of pharmacy systems and organization.

The design and synthesis of chemical/organic compounds with biological activity and potential use in treatment of disease

The analysis, biosynthesis, production, metabolism, and mechanisms of action of pharmaceutically important plants, animals, and microbes

The design, fabrication, and evaluation of advanced drug delivery and advanced drug level management systems

The use of genetic, molecular, cellular, organ system, and whole animal techniques to examine mechanisms and consequences of drug interactions with living systems

The analysis of adverse effects of new biologically active compounds on living systems, such as tissue injury, reproductive failure, immunosuppression, and cancer